We explore how light interacts with biomolecules at extremely small scales. By probing these interactions at the single-molecule level, the lab investigates fundamental light–matter physics and the function of key biological systems, such as enzymes and neurotransmitters. Using advanced laser techniques and optical microcavities, the team develops ultra-sensitive measurements for biomolecular analysis. Our research addresses questions such as how enzyme dynamics enable function, how drugs and anaesthetics affect neurotransmission, and how neuronal membrane receptors process signals, while also driving innovations such as DNA writing technologies, on-chip molecular sensors, the detection of ultra-weak photon emissions, and high-throughput single-molecule microfluidics. The group is integrating its technologies into a Robot Enzymologist platform to rapidly study enzyme mechanisms and accelerate protein engineering cycles. Together with future chip-based quantum optical technologies, these efforts aim to create next-generation tools for precision biosensing, medical diagnostics, and a deeper understanding of fundamental biological function.